Research Articles

  1. Kim MJ, Carmichael PB, Bose U, Honkura Y, Suzuki J, Ding D, Erfe SL, Simms SS, Avaiya KA, Milani MN, Rymer EJ, Fragnito DT, Strom N, Salvi R, Someya S. Sex differences in body composition, voluntary wheel running activity, balance performance, and auditory function in CBA/CaJ mice across the lifespan. Hear Res. 2022 Dec 27;428:108684. doi: 10.1016/j.heares.2022.108684. PMID: 36599258
  2. Kashio A, Yamada C, Yasuhara K, Kamogashira T, Someya S, Yamasoba T. Taurine, Coenzyme Q10, and Hydrogen Water Prevents Germanium Dioxide-Induced Mitochondrial Dysfunction and Associated Sensorineural Hearing Loss in mouse.Hear Res. 2023 Feb;428:108678. doi: 10.1016/j.heares.2022.108678 PMID: 36577362
  3. White K, Someya S. The roles of NADPH and isocitrate dehydrogenase in cochlear mitochondrial antioxidant defense and aging. Hear Res. 2023 Jan;427:108659. doi: 10.1016/j.heares.2022.108659. Epub 2022 Nov 24. PMID: 36493529
  4. Rouse CJ, Hawkins K, Kabbej N, Dalugdug J, Kunta A, Kim MJ, Someya S, Herbst Z, Gelb M, Dinelli I, Butterworth E, Falk DJ, Rosenkrantz E, Elmohd H, Khaledi H, Mowafy S, Ashby F, Heldermon CD. Disease correction in Mucopolysaccharidosis type IIIB mice by intraparenchymal or cisternal delivery of a capsid modified AAV8 codon-optimized NAGLU vector. Hum Mol Genet. 2022 Aug 23:ddac209. doi: 10.1093/hmg/ddac209. PMID: 35997776
  5. Ding D, Prolla T, Someya S, Manohar S, Salvi R. Roles of Bak and Sirt3 in Paraquat-Induced Cochlear Hair Cell Damage. Neurotox Res. 2021 Apr 26. doi: 10.1007/s12640-021-00366-6. PMID: 33900547.
  6. Anton SD, Cruz-Almeida Y, Singh A, Alpert J, Bensadon B, Cabrera M, Clark DJ, Ebner NC, Esser KA, Fillingim RB, Goicolea SM, Han SM, Kallas H, Johnson A, Leeuwenburgh C, Liu AC, Manini TM, Marsiske M, Moore F, Qiu P, Mankowski RT, Mardini M, McLaren C, Ranka S, Rashidi P, Saini S, Sibille KT, Someya S, Wohlgemuth S, Tucker C, Xiao R, Pahor M. Innovations in Geroscience to enhance mobility in older adults. Exp Gerontol. 2020 Dec;142:111123. doi: 10.1016/j.exger.2020.111123. Epub 2020 Oct 22. PMID: 33191210
  7. Kim MJ, Han C, White K, Park HJ, Ding D, Boyd K, Rothenberger C, Bose U, Carmichael P, Linser PJ, Tanokura M, Salvi R, Someya S. Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan. Exp Gerontol. 2020 Nov;141:111078. doi: 10.1016/j.exger.2020.111078. Epub 2020 Aug 28. PMID: 32866605.
  8. Someya S, Kim M. Cochlear Detoxification: Role of Alpha Class Glutathione Transferases in Protection Against Oxidative Lipid Damage, Ototoxicity, and Cochlear Aging. Hear Res. 2020 May 28;108002. doi: 10.1016/j.heares.2020.108002.
  9. Park HJ, Kim MJ, Han C, White K, Ding D, Boyd K, Salvi R, Someya S. Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice. Exp Gerontol. 2020:110872.
  10. Anagnostou ME, Burke SS, Konokhova Y, Ferguson C, Fenton A, Kim MJ, Someya S, Hepple RT. Mitochondrial DNA Mutations Induce Neuromuscular Junction Degeneration. The FASEB Journal. 2019: 33(S1):701.8-701.8
  11. Kaitlyn R. Calabro KR, Boye SL, Choudhury S, Fajardo D, Peterson JJ, Wei Li W, Crosson SM, Kim MJ, Ding D, Salvi R, Someya S, Boye SE. A Novel Mouse Model of MYO7A USH1B Reveals Auditory and Visual System Haploinsufficiencies. Front Neurosci. 2019; 13: 1255.
  12. Suzuki J, Inada H, Han C, Kim MJ, Kimura R, Takata Y, Honkura Y, Owada Y, Kawase T, Katori Y, Someya S, Osumi N. “Passenger gene” problem in transgenic C57BL/6 mice used in hearing research. Neurosci Res. 2019: S0168-0102(19)30469-9.
  13. Park HJ, Kim MJ, Rothenberger C, Kumar A, Sampson EM, Ding D, Han C, White K, Boyd K, Manohar S, Kim YH, Ticsa MS, Gomez AS, Caicedo I, Bose U, Linser PJ, Miyakawa T, Tanokura M, Foster TC, Salvi R, Someya S. GSTA4 Mediates Reduction of Cisplatin Ototoxicity in Female Mice. Nat Commun. 2019: 10(1):4150.
  14. Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Exp Gerontol. 2019: 125:110675.
  15. White K, Kim MJ, Han C, Park HJ, Ding D, Boyd K, Walker L, Linser P, Meneses Z, Slade C, Hirst J, Santostefano K, Terada N, Miyakawa T, Tanokura M, Salvi R, Someya S. Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice. Sci Rep. 2018 Mar 22;8(1):5039. PMID: 29567975.
  16. Xu Y, Liu L, Nakamura A, Someya S, Miyakawa T, Tanokura. Studies on the regulatory mechanism of isocitrate dehydrogenases 2 using acetylation mimics. Sci Rep. 2017 Aug 29;7(1):9785. PMID: 28852116.
  17. Zhang C, Sun W, Li J, Xiong B, Frye MD, Ding D, Salvi R, Kim MJ, Someya S, Hu BH. Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. Neuroscience. 2017 Oct 11;361;179-191. PMID: 28818524.
  18. Han C, Kim MJ, Ding D, Park HJ, White K, Walker L, Gu T, Tanokura M, Yamasoba T, Linser P, Salvi R, Someya S. GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR. PLoS One. 2017 Jul 7;12(7):e0180817. PMID: 28686716.
  19. White K, Kim MJ, Ding D, Han C, Park HJ, Meneses Z, Tanokura M, Linser P, Salvi R, Someya S. G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea. J Neurosci. 2017 Jun 7;37(23):5770-5781. PMID: 28473643.
  20. Cho J, Zhang Y, Park SY, Joseph AM, Han C, Park HJ, Kalavalapalli S, Chun SK, Morgan D, Kim JS, Someya S, Mathews CE, Lee YJ, Wohlgemuth SE, Sunny NE, Lee HY, Choi CS, Shiratsuchi T, Oh SP, Terada N. Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. Nat Commun. 2017 Feb 16;8:14477. PMID: 28205519.
  21. Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017 Feb 3;12(2):e0171159. PMID: 28158260.
  22. Han C, Ding D, Lopez MC, Manohar S, Zhang Y, Kim MJ, Park HJ, White K, Kim YH, Linser P, Tanokura M, Leeuwenburgh C, Baker HV, Salvi RJ, Someya S. Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice. J Neurosci. 2016 Nov 2;36(44):11308-11319. PMID: 27807171.
  23. Mankowski RT, Ahmed S, Beaver T, Dirain M, Han C, Hess P, Martin T, Smith BK, Someya S, Leeuwenburgh C, Martin AD. Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study. Journal of Translational Medicine. 2016 Oct 26;14(1):305. PMID: 27784315.
  24. Yu H, Vikhe Patil K, Han C, Fabella B, Canlon B, Someya S, Cederroth CR. GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus. Front Behav Neurosci. 2016 Aug 17;10:158. PMID: 27582696.
  25. Han C, Linser P, Park HJ, Kim MJ, White K, Vann JM, Ding D, Prolla TA, Someya S. Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice. Neurobiol Aging. 2016 July;43:58-71. PMID: 27255815.
  26. Anton SD, Woods AJ, Ashizawa T, Barb D, Buford TW, Carter CS, Clark DJ, Cohen RA, Corbett DB, Cruz-Almeida Y, Dotson V, Ebner N, Efron PA, Fillingim RB, Foster TC, Gundermann DM, Joseph AM, Karabetian C, Leeuwenburgh C, Manini TM, Marsiske M, Mankowski RT, Mutchie HL, Perri MG, Ranka S, Rashidi P, Sandesara B, Scarpace PJ, Sibille KT, Solberg LM, Someya S, Uphold C, Wohlgemuth S, Wu SS, Pahor M. Successful aging: Advancing the science of physical independence in older adults. Ageing Res Rev. 2015 Nov;24(Pt B):304-27. PMID: 26462882.
  27. Fischer KE, Gelfond JA, Soto VY, Han C, Someya S, Richardson A, Austad SN. Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life. PloS One. 2015 May 15;10(5):e0126644. PMID: 25978367.
  28. Barger JL, Anderson RM, Newton MA, da Silva C, Vann JA, Pugh TD, Someya S, Prolla TA, Weindruch R. A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3. PloS One. 2015 April 1;10(4):e0120738. PMID: 25830335.
  29. Ding D, Qi W, Yu D, Jiang H, Han C, Kim MJ, Katsuno K, Hsieh YH, Miyakawa T, Salvi R, Tanokura M, Someya S. Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures. PloS One. 2013 Nov 6;8(11):e79817. PMID: 24223197.
  30. Han C, Someya S. Maintaining good hearing: calorie restriction, Sirt3, and glutathione. Exp Gerontol. 2013 Otc;48(10):1091-5. PMID: 23454634.
  31. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res. 2013 Sep;303:30-8. PMID: 23422312.
  32. Dalian D, Haiyan J, Yong F, Yongqi L, Salvi R, Someya S, Tanokura M. Ototoxic model of oxaliplatin and protection from nicotinamide adenine dinucleotide. J Otol. 2013;8(1):63-71. PMID: 25419212.
  33. Dalian D, Haiyan J, Yong F, Salvi R, Someya S, Tanokura M. Ototoxic effects of carboplatin in organotypic cultures in chinchillas and rats. J Otol. 2012 Dec;7(2):92-101. PMID: 25593588.
  34. Han C, Someya S. Mouse models of age-related mitochondrial neurosensory hearing loss. Mol Cell Neurosci. 2013 Jul;55:95-100. PMID: 22820179.
  35. Someya S and Tanokura M. Mitochondria and Aging. Jikenigaku. 2013;31 (20) 141-147 (in Japanese).
  36. Lee WH, Kumar A, Rani A, Herrera J, Xu J, Someya S, Foster TC. Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging. Antioxid Redox Signal. 2012 Feb 15;16(4):339-50. PMID: 21942371.
  37. Dalian Ding, Someya S, Jiang H, Wei–dong Qi, Yu D, Masaru T, Salvi R. Detection of apoptosis by RT–PCR array in mefloquine–induced cochlear damage. J Otol. 2011;June; 6(1):1-9.
  38. Someya S. Molecular mechanism of how caloric restriction prevents age-related hearing loss Jikenigaku. 2011;29. 2673-2676 (in Japanese).
  39. Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell. 2011 Jan 21;41(2):139-49. PMID: 21255725.
  40. Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010 Nov 24;143(5):802-12. PMID: 21094524.
  41. Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-Otín M, Tanokura M, Prolla TA, Leeuwenburgh C. Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PloS One. 2010 Jul 7;5(7):e11468. PMID: 20628647.
  42. Someya S, Prolla TA. Mitochondrial oxidative damage and apoptosis in age-related hearing loss. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):480-6. PMID: 20434479.
  43. Someya S, Tanokura M, Weindruch R, Prolla TA, Yamasoba T. Effects of caloric restriction on age-related hearing loss in rodents and rhesus monkeys. Curr Aging Sci. 2010 Feb;3(1):20-5. PMID: 20298166.
  44. Someya S and Tanokura M. Bak-dependent mitochondrial apoptosis in Age-related Hearing Loss. Jikenigaku. 2010;28, 917-920 (In Japanese).
  45. Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19432-7. PMID: 19901338.
  46. Someya S, Yamasoba T, Prolla TA, Tanokura M. Genes encoding mitochondrial respiratory chain components are profoundly down-regulated with aging in the cochlea of DBA/2J mice. Brain Res. 2007 Nov 28;1182:26-33. PMID: 17964557.
  47. Someya S, Yamasoba T, Kujoth GC, Pugh TD, Weindruch R, Tanokura M, Prolla TA. The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiol Aging. 2008 Jul;29(7):1080-92. PMID: 17363114.
  48. Someya S, Yamasoba T, and Tanokura M. Presbycusis and Calorie Restriction. Anti-Aging Mecicine. 2008;4, 614-620 (In Japanese).
  49. Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiol Aging. 2007 Oct;28(10):1613-22. PMID: 16890326.
  50. Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla TA, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res. 2007 Apr;226(1-2):185-93. PMID: 16870370.
  51. Yamasoba T, Someya S, Tanokura M. Mechanisms of presbycusis and its prevention by caloric restriction. Otology Japan. 2006; 16(2):131-134.
  52. Someya S, Tanokura M, and Yamasoba T. Mitochondrial DNA mutations and presbycusis. JOHNS, 2006; 22, 1711-1714 (In Japanese).
  53. Someya S, and Tanokura M. Mitochondrial DNA mutations, apoptosis, and presbycusis. Brain Techno News, 2005; 112, 20-24 (In Japanese).
  54. Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005 July 15;309(5733):481-4. PMID: 16020738.
  55. Suzuki T, Someya S, Hu F, Tanokura M. Comparative study of catechin composition in five Japanese persimmons (Diospyros kaki). Food Chemistry. 2005;93(1):149-152.
  56. Fujikawa T., Manabe Y, and Someya S. Atmosphere controlled sintering of coral sand powders by hot isostatic pressing. Powder and Powder Metallurgy, 2005; 52, 28-34 (In Japanese).
  57. Fujimura H, Oomori T, Kouch S, and Someya S. Synthesis of protodolomite from coral reef sand. Food Chemistry. 2005; 99, 15-18.
  58. Someya S, Nuno K, Kuriyama Y, and Sato N. Mineral composition of coral mineral powder. Journal of Japanese Society for Magnesium in Research, 2005; 32, 28-34 (In Japanese).
  59. Someya S, Yoshiki Y, Okubo K. Antioxidant compounds from bananas (Musa Cavendish). Food Chemistry. 2002 November; 79(3):351-354.
  60. Iida T, Yoshiki Y, Someya S, Okubo K Generation of reactive oxygen species and photon emission from a browned product. Biosci Biotechnol Biochem. 2002 Aug;66(8):1641-5. PMID: 12353622.
  61. Someya S., Yoshiki Y, Tanokura M, and Okubo K. Antioxidant activities of banana extracts. Japan Food Science, 2002; 41, 101-104 (In Japanese).

Chapter Books

  1. Someya S, Kim MJ. Genetic Aspects of the Aging Auditory System in The Aging Auditory System (Springer Handbook of Auditory Research (34)) 2020th Edition. Karen Helfer, Ed Bartlett, Art Popper, Dick Fay (Eds.). SpringerNature 2020; ISBN 978-3-030-49366-0.
  2. Someya S, Ikeda A. Aging of the Sensory Systems: Hearing and Vision in Handbook of the Biology of Aging (Handbooks of Aging) 9th Edition. Nicolas Musi, Peter Hornsby (Eds.). SpringerNature 2020; ISBN-10: 0128159626 (in press).
  3. Someya S, Rothenberger C, Kim MJ. Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction in New Therapies to Prevent or Cure Auditory Disorders. Pucheu, Sylvie, Radziwon, Kelly, Salvi, Richard (Eds.). SpringerNature 2020; ISBN 978-3-030-40413-0
  4. Kim MJ, White K, Walker L, Han C, Someya S. Age-related Hearing Loss: Biochemical Pathways and Molecular Targets in Free Radicals in ENT pathology. Miller J, LePrell CG, Rybak L, editors. USA: Humana Press, 2015; 13, p.273-288. 502p.
  5. Han Chul, Someya S. Update on the Free Radical Theory of Aging: The Role of Oxidative Stress in Age-related Hearing Loss in Systems Biology of Free Radicals and Anti-oxidants. Laher Issy, editor. Berlin Heidelberg, Germany: Springer-Verlag. 2014; 158, p.3581-98. 4108 p.
  6. Someya S, Prolla TA., Tanokura M. Effects of Nutraceuticals Antioxidants on Age-related Hearing Loss in Biotechnology in Functional Foods and Nutraceuticals. Bagchi D, Lau FC, Ghosh DK, editors. Boca Raton, FL, USA: CRC Press. 2010; 8, p.113-124. 591p.
  7. Yamasoba T and Someya Hearing Loss and Anti-aging in Understanding Hearing Disorder. Ogawa, I., eds. Nagai Press. 2010; 356-341 (In Japanese).
  8. Someya S, Yamasoba T, Tanokura M. Prevention of presbycusis by caloric restriction in New otolaryngology and head and neck surgery. Kaga K, Komune S, editors. Japan: Sentaniryogijitsu Kennkyujo; 2005; p.110-113 (In Japanese).
  9. Miyagawa M, Someya S., and Tanokura M. Mechanisms of Anti-aging enzymes in Structural Biology. Kyoritsu Press. 2005; 65-172 (In Japanese).