Congratulations to Dr. Shinichi Someya for his newly awarded NIH/NIDCD R01 grants

Congratulations to Dr. Shinichi Someya for his newly awarded NIH/NIDCD R01 grants

  • NIH/NIDCD RO1 R01DC014437
    Title: Cochlear Detoxification System

Living organisms are continuously exposed to and must defend against naturally occurring toxins and non-nutrient foreign chemicals (1-3). The glutathione transferase (GST) detoxification system converts a non-polar toxic compound into a more water-soluble and less toxic form by conjugating the toxic compound to reduced glutathione by a variety of GST enzymes. The overall goal of our research proposal is to provide new basic knowledge of the molecular basis for the cochlear detoxification system and its role in the elimination of non-nutrient foreign chemicals and naturally occurring toxins throughout the lifespan. Understanding the mechanism of action of cochlear detoxification may define novel therapeutic approaches for human hearing loss induced by drugs, chemicals, or naturally occurring toxins.

  • NIH/NIDCD RO1 RO1DC012552
    Title: Mitochondrial Thioredoxin, Caloric restriction, and Age-related Hearing Loss